eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| malignant peritoneal mesothelioma | ||||
| Disease ID | 624 |
|---|---|
| Disease | malignant peritoneal mesothelioma |
| Definition | An aggressive malignant mesothelioma that arises from the peritoneum. Patients usually present with abdominal pain and ascites. |
| Synonym | cancer of the peritoneum, mesothelioma malignant mesothelioma of peritoneum malignant mesothelioma of peritoneum (disorder) malignant mesothelioma of the peritoneum mesothelioma of peritoneum mesothelioma peritoneum peritoneal malignant mesothelioma peritoneal mesothelioma |
| Orphanet | |
| DOID | |
| ICD10 | |
| UMLS | C0346109 |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:12) C0019322 | umbilical hernia | 1 C0027726 | nephrotic syndrome | 1 C0345967 | malignant mesothelioma | 1 C0001418 | adenocarcinoma | 1 C0338106 | colonic adenocarcinoma | 1 C0476089 | endometrial cancer | 1 C0079419 | li-fraumeni syndrome | 1 C1377913 | pleural mesothelioma | 1 C0862312 | epithelioid mesothelioma | 1 C0014175 | endometriosis | 1 C0020598 | hypoglycemia | 1 C0476089 | endometrial ca | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:41) 8038 | ADAM12 | 1.521 | DISEASES 8754 | ADAM9 | 1.575 | DISEASES 8314 | BAP1 | 3.392 | DISEASES 800 | CALD1 | 1.062 | DISEASES 6358 | CCL14 | 2.173 | DISEASES 942 | CD86 | 2.649 | DISEASES 1029 | CDKN2A | 2.615 | DISEASES 1654 | DDX3X | 1.852 | DISEASES 646480 | FABP9 | 2.337 | DISEASES 2526 | FUT4 | 2.201 | DISEASES 5348 | FXYD1 | 2.458 | DISEASES 81621 | KAZALD1 | 3.607 | DISEASES 3855 | KRT7 | 1.871 | DISEASES 26524 | LATS2 | 2.446 | DISEASES 10232 | MSLN | 3.408 | DISEASES 2475 | MTOR | 1.169 | DISEASES 4582 | MUC1 | 1.335 | DISEASES 4771 | NF2 | 2.203 | DISEASES 246734 | NPCDR1 | 1.331 | DISEASES 64324 | NSD1 | 1.453 | DISEASES 93034 | NT5C1B | 2.329 | DISEASES 7849 | PAX8 | 2.23 | DISEASES 9659 | PDE4DIP | 2.883 | DISEASES 5154 | PDGFA | 1.048 | DISEASES 23481 | PES1 | 1.097 | DISEASES 5586 | PKN2 | 2.031 | DISEASES 5935 | RBM3 | 2.128 | DISEASES 253260 | RICTOR | 1.291 | DISEASES 862 | RUNX1T1 | 1.132 | DISEASES 29072 | SETD2 | 1.282 | DISEASES 6513 | SLC2A1 | 1.121 | DISEASES 23583 | SMUG1 | 2.582 | DISEASES 7056 | THBD | 2.692 | DISEASES 161291 | TMEM30B | 3.459 | DISEASES 7153 | TOP2A | 1.784 | DISEASES 7155 | TOP2B | 1.437 | DISEASES 10381 | TUBB3 | 1.152 | DISEASES 7422 | VEGFA | 1.278 | DISEASES 7490 | WT1 | 3.487 | DISEASES 331 | XIAP | 1.179 | DISEASES 7514 | XPO1 | 1.22 | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 624 |
|---|---|
| Disease | malignant peritoneal mesothelioma |
| Integrated Phenotype | HPO | Name(Total Integrated Phenotypes:10) HP:0003270 | Abdominal distention HP:0002094 | Dyspnea HP:0002664 | Neoplasm HP:0010741 | Edema of the lower limbs HP:0001928 | Abnormality of coagulation HP:0002595 | Ileus HP:0002027 | Abdominal pain HP:0001824 | Weight loss HP:0001541 | Ascites HP:0002586 | Peritonitis |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:9) HP:0002664 | Neoplasia | 2 HP:0100001 | Malignant mesothelioma | 1 HP:0001537 | Umbilical hernias | 1 HP:0000100 | Nephrosis | 1 HP:0001943 | Hypoglycemia | 1 HP:0100002 | Pleural mesothelioma | 1 HP:0004872 | Recurrent abdominal hernia | 1 HP:0001945 | Fever | 1 HP:0030127 | Endometriosis | 1 |
| Disease ID | 624 |
|---|---|
| Disease | malignant peritoneal mesothelioma |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:3) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:1) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:3) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0010741 | Edema of the lower limbs | MP:0009657 | failure of chorioallantoic fusion | failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois |
| HP:0001824 | Weight loss | MP:0005114 | premature hair loss | release of fur at an earlier than expected time |
| HP:0001928 | Abnormality of coagulation | MP:0013283 | failure of ventral body wall closure | failure of the lateral body wall folds (a combination of mesoderm and ectoderm arising on each side of the embryo) to progress ventrally and meet in the midline and/or fuse to close the ventral body wall; normally, this closure is aided by growth of the h |
Mapped by homologous gene(Total Items:10) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0002094 | Dyspnea | MP:0014185 | cerebellum atrophy | acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal |
| HP:0001824 | Weight loss | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0002664 | Neoplasm | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0002586 | Peritonitis | MP:0011085 | postnatal lethality, complete penetrance | premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age) |
| HP:0003270 | Abdominal distention | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0002027 | Abdominal pain | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0002595 | Ileus | MP:0020234 | decreased basal metabolism | decrease in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state |
| HP:0001928 | Abnormality of coagulation | MP:0020039 | increased bone ossification | increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance |
| HP:0001541 | Ascites | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0010741 | Edema of the lower limbs | MP:0013258 | abnormal extracellular matrix morphology | any structural anomaly of the structure lying external to one or more cells, which provides structural support for cells or tissues; in mammals, the extracellular matrix is completely external to the cell |
| Disease ID | 624 |
|---|---|
| Disease | malignant peritoneal mesothelioma |
| Case | (Waiting for update.) |